The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis
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چکیده
منابع مشابه
The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1
Telomere integrity (including telomere length and capping) is critical in overall genomic stability. Telomere repeat binding factors and their associated proteins play vital roles in telomere length regulation and end protection. In this study, we explore the protein network surrounding telomere repeat binding factors, TRF1, TRF2, and POT1 using dual-tag affinity purification in combination wit...
متن کاملMAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap
In meiosis, telomeres attach to the inner nuclear membrane (INM) and drive the chromosome movement required for homolog pairing and recombination. Here, we address the question of how telomeres are structurally adapted for the meiotic task. We identify a multi-subunit meiotic telomere-complex, TERB1/2-MAJIN, which takes over telomeric DNA from the shelterin complex in mouse germ cells. TERB1/2-...
متن کاملThe meiosis-specific modification of mammalian telomeres
During meiosis, rapid chromosome movements within the nucleus enable homologous chromosomes to acquire physical juxtaposition. In most organisms, chromosome ends, telomeres, tethered to the transmembrane LINC-complex mediate this movement by transmitting cytoskeletal forces to the chromosomes. While the majority of molecular studies have been performed using lower eukaryotes as model systems, r...
متن کاملA Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2
BACKGROUND Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function independently to regulate telomere length and protect chromosome ends, respectively. RESULTS Here, we show that TRF1 and TRF2 are linked via TIN2, a previously identified TRF1-interacting protein, and its novel binding partner TINT1. TINT1 localized to telomeres via TIN2...
متن کاملTelomere binding of the Rap1 protein is required for meiosis in fission yeast
Telomeres are essential for chromosome integrity, protecting the ends of eukaryotic linear chromosomes during cell proliferation. Telomeres also function in meiosis; a characteristic clustering of telomeres beneath the nuclear membrane is observed during meiotic prophase in many organisms from yeasts to plants and humans, and the role of the telomeres in meiotic pairing and the recombination of...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2014
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2896